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Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens

21 Jun 2019

Abstract excerpt

Rotavirus is the leading agent causing acute gastroenteritis in young children, with the P[8] genotype accounting for more than 80% of infections in humans. The molecular bases for binding of the VP8* domain from P[8] VP4 spike protein to its cellular receptor, the secretory H type-1 antigen (Fuc-α1,2-Gal-β1,3-GlcNAc; H1), and to its precursor lacto-N-biose (Gal-β1,3-GlcNAc; LNB) have been determined. The...

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PMID: 31226167
DOI: 10.1371/journal.ppat.1007865

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