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Article

Characterization of Sialic Acid-Independent Simian Rotavirus Mutants in Viral Infection and Pathogenesis.

Journal of virology - 31 Jan 2023

Yamasaki Moeko, Kanai Yuta, Wakamura Yoshiki, Kotaki Tomohiro, Minami Shohei, Nouda Ryotaro, Nurdin Jeffery A, Kobayashi Takeshi

Abstract excerpt

Rotaviruses (RVs) are nonenveloped viruses that cause gastroenteritis in infants and young children. Sialic acid is an initial receptor, especially for animal RVs, including rhesus RV. Sialic acid binds to the VP8* subunit, a part of the outer capsid protein VP4 of RV. Although interactions between virus and glycan receptors influence tissue and host tropism and viral pathogenicity, research has long been limited...

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Identifiers

PMID: 36602365
DOI: 10.1128/jvi.01397-22
PMCID: PMC9888295

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Characterization of Sialic Acid-Independent Simian Rotavirus Mutants in Viral Infection and Pathogenesis.PMID 36602365Read ↗

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