Article
β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
The American journal of pathology - 1 Dec 2011
Clark Peter E, Polosukhina Dina, Love Harold, Correa Hernan, Coffin Cheryl, Perlman Elizabeth J, de Caestecker Mark, Moses Harold L, Zent Roy
Abstract excerpt
Wilms' tumor (WT) is the most common childhood renal cancer. Although mutations in known tumor-associated genes (WT1, WTX, and CATNB) occur only in a third of tumors, many tumors show evidence of activated β-catenin-dependent Wnt signaling, but the molecular mechanism by which this occurs is unknown. A key obstacle to understanding the pathogenesis of WT is the paucity of mouse models that recapitulate its...
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