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Stress-induced visceral pain in female rats is associated with epigenetic remodeling in the central nucleus of the amygdala

19 Sept 2021

Abstract excerpt

Stress and anxiety contribute to the pathophysiology of irritable bowel syndrome (IBS), a female-predominant disorder of the gut-brain axis, characterized by abdominal pain due to heightened visceral sensitivity. In the current study, we aimed to evaluate in female rats whether epigenetic remodeling in the limbic brain, specifically in the central nucleus of the amygdala (CeA), is a contributing factor in...

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PMID: 34584907
DOI: 10.1016/j.ynstr.2021.100386

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