Article
A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men.
American journal of hypertension - 1 Nov 2008
Fu Zhenyan, Nakayama Tomohiro, Sato Naoyuki, Izumi Yoichi, Kasamaki Yuji, Shindo Atsushi, Ohta Masakatsu, Soma Masayoshi, Aoi Noriko, Sato Mikano, Matsumoto Koichi, Ozawa Yukio, Ma Yitong
Abstract excerpt
BACKGROUND: CYP4F2, a member of the cytochrome P450 family, acts mainly as an enzyme and is involved not only in the metabolism of leukotriene B4, but also in that of arachidonic acid. It converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite involved in the regulation of the vascular tone in the brain. The aim of this study was to assess the association between the human CYP4F2 gene...
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