Article
A haplotype-based case-control study examining human extracellular superoxide dismutase gene and essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Aug 2008
Naganuma Takahiro, Nakayama Tomohiro, Sato Naoyuki, Fu Zhenyan, Soma Masayoshi, Aoi Noriko, Usami Ron
Abstract excerpt
It has been reported that oxidative stress is involved in the pathophysiology of essential hypertension (EH), which is a multifactorial disorder. Extracellular superoxide dismutase (EC-SOD) protects the human body from oxidative stress by converting the toxic superoxide anion (O2-) into less toxic hydrogen peroxide (H2O2). In EC-SOD knockout mice, blood pressure was reported to be significantly higher than that...
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