Article
DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation.
American journal of human genetics - 10 Jun 2011
Gusev Alexander, Kenny Eimear E, Lowe Jennifer K, Salit Jaqueline, Saxena Richa, Kathiresan Sekar, Altshuler David M, Friedman Jeffrey M, Breslow Jan L, Pe'er Itsik
Abstract excerpt
Rare variants affecting phenotype pose a unique challenge for human genetics. Although genome-wide association studies have successfully detected many common causal variants, they are underpowered in identifying disease variants that are too rare or population-specific to be imputed from a general reference panel and thus are poorly represented on commercial SNP arrays. We set out to overcome these challenges and...
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