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Article

Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells.

PloS one - 1 Jan 2012

Guo Yan, Xu Wen-Wen, Song Jie, Deng Wen, Liu Di-Qiu, Zhang Hua-Tang

Abstract excerpt

Nef functions as an immunosuppressive factor critical for HIV-1 replication, survival and development of AIDS following HIV-1 infection. What effects Nef exerts on differentiation and maturation of monocytes towards dendritic cells (DCs) remains greatly controversial. In this study, we used THP-1 (human monocytic leukemia cell line) as monocytic DC precursors to investigate how overexpression of HIV-1 Nef...

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Source

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Identifiers

PMID: 22808111
DOI: 10.1371/journal.pone.0040179
PMCID: PMC3392284

Genes

CCR5
CXCR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells.PMID 22808111Read ↗

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