Article
Rapid high resolution single nucleotide polymorphism-comparative genome hybridization mapping in Caenorhabditis elegans.
Genetics - 1 Jan 2009
Flibotte Stephane, Edgley Mark L, Maydan Jason, Taylor Jon, Zapf Rick, Waterston Robert, Moerman Donald G
Abstract excerpt
We have developed a significantly improved and simplified method for high-resolution mapping of phenotypic traits in Caenorhabditis elegans using a combination of single nucleotide polymorphisms (SNPs) and oligo array comparative genome hybridization (array CGH). We designed a custom oligonucleotide array using a subset of confirmed SNPs between the canonical wild-type Bristol strain N2 and the Hawaiian isolate...
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