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Transposable elements and heterochromatic regions are enriched for structural variation and sequence divergence in the genome of wild-type Caenorhabditis elegans.

G3 (Bethesda, Md.) - 9 Jul 2025

Bush Zachary D, Naftaly Alice F S, Dinwiddie Devin, Albers Cora, Hillers Kenneth J, Libuda Diana E

Abstract excerpt

Genomic structural variants (SVs) and transposable elements (TEs) can be significant contributors to genome evolution, gene expression alterations, and genetic disease risk. Recent advancements in long-read sequencing have greatly improved the quality of de novo genome assemblies and enhanced the detection of larger and highly repetitive sequence variants at the scale of hundreds or thousands of bases....

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PMID: 40305774
DOI: 10.1093/g3journal/jkaf092
PMCID: PMC12239620

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