De Novo identification of single nucleotide mutations in Caenorhabditis elegans using array comparative genomic hybridization.

Abstract excerpt

Array comparative genomic hybridization (aCGH) has been used primarily to detect copy-number variants between two genomes. Here we report using aCGH to detect single nucleotide mutations on oligonucleotide microarrays with overlapping 50-mer probes. This technique represents a powerful method for rapidly detecting novel homozygous single nucleotide mutations in any organism with a sequenced reference genome.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Caenorhabditis elegans