Article
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism.
Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Sept 2008
Copaja Soto Miguel, Valenzuela Rodrigo, Saldaña Adiela, Paz Ocaranza María, Jalil Jorge E, Vio Carlos, Lijnen Paul, Ordenes Gamaliel E, Vivar Sanchez Raul, Lavandero Sergio, Díaz-Araya Guillermo
Abstract excerpt
INTRODUCTION: Isoproterenol treatment of Brown Norway and Lewis rats (high and low plasma angiotensin-I-converting enzyme activity, respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown Norway rats. MATERIALS AND METHODS: Rats were infused in vivo with isoproterenol for two or 10 days. Cardiac fibrosis and inflammation were evaluated histochemically. We measured the mRNAs of...
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