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Article

Persistent change in cardiac fibroblast physiology after transient ACE inhibition.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2015

D'Souza K M, Biwer L A, Madhavpeddi L, Ramaiah P, Shahid W, Hale T M

Abstract excerpt

Transient angiotensin-converting enzyme (ACE) inhibition induces persistent changes that protect against future nitric oxide synthase (NOS) inhibitor-induced cardiac fibrosis and inflammation. Given the role of fibroblasts in mediating these effects, the present study investigates whether prior ACE inhibition produced persistent changes in cardiac fibroblast physiology. Adult male spontaneously hypertensive rats...

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Source

Identifiers

PMID: 26371174
DOI: 10.1152/ajpheart.00615.2015

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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