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Article

IGF-1 Modulation of Rat Cardiac Fibroblast Behavior and Gene Expression is Age-Dependent

1 Jan 2003

Abstract excerpt

The collagenous extracellular matrix (ECM) forms a stress-tolerant network that is essential for proper function of the vertebrate heart. Profound changes have been detected in the interstitial ECM concurrent with developmental and disease processes of the heart. These alterations in either the organization or accumulation of ECM components markedly affect myocardial function. Studies have shown that a number of...

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PMID: 14668062
DOI: 10.1080/15419060390262598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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