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Article

Aldosterone induces a vascular inflammatory phenotype in the rat heart.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2002

Rocha Ricardo, Rudolph Amy E, Frierdich Gregory E, Nachowiak Denise A, Kekec Beverly K, Blomme Eric A G, McMahon Ellen G, Delyani John A

Abstract excerpt

Vascular inflammation was examined as a potential mechanism of aldosterone-mediated myocardial injury in uninephrectomized rats receiving 1% NaCl-0.3% KCl to drink for 1, 2, or 4 wk and 1) vehicle, 2) aldosterone infusion (0.75 microg/h), or 3) aldosterone infusion (0.75 microg/h) plus the selective aldosterone blocker eplerenone (100 mg. kg(-1). day(-1)). Aldosterone induced severe hypertension at 4 wk [systolic...

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Source

Identifiers

PMID: 12384457
DOI: 10.1152/ajpheart.01096.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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