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Article

Association of epidermal growth factor receptor (EGFR) gene mutations with EGFR amplification in advanced non-small cell lung cancer.

Cancer science - 1 Dec 2008

Morinaga Ryotaro, Okamoto Isamu, Fujita Yoshihiko, Arao Tokuzo, Sekijima Masaru, Nishio Kazuto, Ito Hiroyuki, Fukuoka Masahiro, Kadota Jun-Ichi, Nakagawa Kazuhiko

Abstract excerpt

Somatic mutations in the epidermal growth factor receptor (EGFR) gene are associated with the response to EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer (NSCLC). Increased EGFR copy number has also been associated with sensitivity to these drugs. However, given that it is often difficult to obtain sufficient amounts of tumor tissue for genetic analysis from patients with advanced...

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Identifiers

PMID: 18957054
DOI: 10.1111/j.1349-7006.2008.00962.x
PMCID: PMC11158508

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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