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Article

Correlation between encoded protein overexpression and copy number of the <i>HER2</i> gene with survival in non‐small cell lung cancer

26 Nov 2002

Abstract excerpt

The HER2 oncogene, which encodes the tyrosine kinase receptor, is commonly overexpressed in several types of cancer. Treatment using a humanized monoclonal antibody bound to HER2 product is becoming standard therapy for advanced breast cancer. Overexpression occurs in approximately 30% of non-small cell lung cancers (NSCLCs) and has been associated with poor prognosis. However, the frequency of a genetic...

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PMID: 12455054
DOI: 10.1002/ijc.10795

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