Article
Low frequency and variability of FLT3 mutations in Korean patients with acute myeloid leukemia.
Journal of Korean medical science - 1 Oct 2008
Bang Soo-Mee, Ahn Jeong Yeal, Park Jiyoon, Park Se Hoon, Park Jinny, Cho Eun Kyung, Shin Dong Bok, Lee Jae Hoon, Yoo Soo Jin, Jeon In Sang, Kim Yeo-Kyeoung, Kim Hyeoung Joon, Kim Hee-Nam, Lee Il-Kwon, Kang Hyoung Jin, Shin Hee Young, Ahn Hyo Seop
Abstract excerpt
FLT3 mutations are common genetic changes, and are reported to have prognostic significance in acute myeloid leukemia (AML). The FLT3 internal tandem duplication (ITD) and the D835 activating mutation in the tyrosine kinase domain (TKD) were analyzed by polymerase chain reaction (PCR) in the genomic DNA of Korean patients with AML at diagnosis and during follow-up. There were 226 patients with AML enrolled...
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