Article
Molecular typing of HLA genes using whole genome amplified DNA.
Transfusion - 1 Jan 2009
Creary Lisa E, Girdlestone John, Zamora Jorge, Brown Juliette, Navarrete Cristina V
Abstract excerpt
BACKGROUND: The outcome of clinical transplantation and a number of disease susceptibilities show very strong associations with genetic variants within the major histocompatibility complex, particularly in the human leukocyte antigen (HLA) genes. A problem with many association studies is the lack of sufficient DNA to perform multiple genetic analyses, particularly with transplantation outcomes where donor and...
Topics
- Genome, Human
- Genotype
- Histocompatibility Testing
- Humans
- Polymerase Chain Reaction
- Sensitivity and Specificity