Article
No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids.
Advances in medical sciences - 1 Jan 2008
Szczepankiewicz A, Breborowicz A, Sobkowiak P, Popiel A
Abstract excerpt
PURPOSE: Glucocorticoids are the most effective anti-inflammatory drugs in asthma therapy. They act via receptors localized in target cells that after activation by glucocorticoids may affect expression of inflammatory genes thus reducing inflammation in asthma. However, 10-20% of patients, particularly with severe, difficult-to-treat asthma may not respond well to glucocorticoids and remain symptomatic even...
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