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Article

Pael‐R is accumulated in Lewy bodies of Parkinson's disease

20 Feb 2004

Abstract excerpt

We examined the distribution of Pael-R, a newly identified substrate for Parkin, in Parkinson's disease (PD) and multiple system atrophy (MSA). Pael-R, Parkin, alpha-synuclein, and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael-R was localized in the core of LBs. Parkin and alpha-synuclein accumulated in the halo, neuronal cell bodies, and processes. These findings potentially suggest the...

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PMID: 14991825
DOI: 10.1002/ana.20064

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