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Structural elucidation of the Cys‐His‐Glu‐Asn proteolytic relay in the secreted CHAP domain enzyme from the human pathogen <i>Staphylococcus saprophyticus</i>

18 Sept 2008

Abstract excerpt

Cysteine peptidases (CP) are ubiquitous enzymes that play fundamental roles in many cellular metabolic pathways.1 In mammalian cells, they are highly regulated in apoptotic pathways related to cancer and other severe disorders.2, 3 In bacterial cell division, cell-growth and lysis, peptidases are employed in the cleavage of peptidoglycans (autolysins).4, 5 As secreted antigens and toxins, CPs are key to virulence...

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PMID: 18951393
DOI: 10.1002/prot.22267

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