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Article

Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureus.

Structure (London, England : 1993) - 3 Apr 2018

Stach Natalia, Kalinska Magdalena, Zdzalik Michal, Kitel Radoslaw, Karim Abdulkarim, Serwin Karol, Rut Wioletta, Larsen Katrine, Jabaiah Abeer, Firlej Magdalena, Wladyka Benedykt, Daugherty Patrick, Stennicke Henning, Drag Marcin, Potempa Jan, Dubin Grzegorz

Abstract excerpt

Staphylococcus aureus is a dangerous human pathogen characterized by alarmingly increasing antibiotic resistance. Accumulating evidence suggests the role of Spl proteases in staphylococcal virulence. Spl proteases have restricted, non-overlapping substrate specificity, suggesting that they may constitute a first example of a proteolytic system in bacteria. SplA, SplB, and SplD were previously characterized in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29526434
DOI: 10.1016/j.str.2018.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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