Article
Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer.
Oncology reports - 1 Nov 2008
Sasaki Hidefumi, Okuda Katsuhiro, Kawano Osamu, Yukiue Haruhiro, Yano Motoki, Fujii Yoshitaka
Abstract excerpt
We investigated the FGFR4 mutation status at the kinase domain and FGFR4 single nucleotide polymorphism (SNP) at codon 388 in surgically treated non-small cell lung cancer (NSCLC) cases. The presence or absence of FGFR4 mutations of kinase domains was analyzed by direct sequences (n=147), and the presence of FGFR4 Arg388 allele was analyzed by genotyping assay using LightCycler hybridization probes (n=387). FGFR4...
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