Article
Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.
RNA (New York, N.Y.) - 1 Jun 2005
Dey Antu K, Griffiths Carla, Lea Susan M, James William
Abstract excerpt
We recently described the isolation of 2'-fluoropyrimidine-substituted RNA aptamers that bind specifically to the surface glycoprotein (gp 120) of the R5 strain, HIV-1(Ba-L), as presented in a previous study. These aptamers potently neutralize HIV-1 infectivity in human peripheral blood mononuclear cells of both tissue culture lab-adapted strains and diverse R5 clinical isolates from multiple clades. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.