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Article

Identification and recovery of minor HIV-1 variants using the heteroduplex tracking assay and biotinylated probes.

Nucleic acids research - 1 Dec 2008

Schnell Gretja, Ince William L, Swanstrom Ronald

Abstract excerpt

We describe a method to identify and recover minor human immunodeficiency virus type 1 (HIV-1) sequence variants from a complex population. The original heteroduplex tracking assay (HTA) was modified by incorporating a biotin tag into the probe to allow for direct sequence determination of the query strand. We used this approach to recover sequences from minor HIV-1 variants in the V3 region of the env gene, and...

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Share to Biotinylation
Share to Drug Resistance, Viral
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heteroduplex Analysis

Share to HIV Protease Inhibitors

Share to Oligonucleotide Probes

Share to Sequence Analysis, DNA

Source

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Identifiers

PMID: 18948297
DOI: 10.1093/nar/gkn713
PMCID: PMC2602764

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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