Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening and validation of dinucleotide repeats in intron 1 of the human EGFR gene and its paralog in the HER2 gene.

Journal of receptor and signal transduction research - 1 Jan 2008

Kharrat Najla, Al'Fadhli Suad, Rebaï Ahmed

Abstract excerpt

Overexpression or dysfunction of EGFR and other ErbBs is known to be involved in many human cancers. The first intron of several genes, including ErbBs, has an important regulatory function in transcription. In intron 1 of the EGFR gene, simple CA repeats (CA-SSR) have been found to be associated with the level of transcriptional modulation of the EGFR both in vitro and in vivo. The aim of this work was to screen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dinucleotide Repeats

Share to ErbB Receptors

Share to Gene Frequency

Share to Polymorphism, Genetic

Share to Receptor, ErbB-2

Share to Young Adult

Source

Identifiers

PMID: 18946768
DOI: 10.1080/10799890802439958

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening and validation of dinucleotide repeats in intron 1 of the human EGFR gene and its paralog in the HER2 gene.PMID 18946768Read ↗

Distinct amplification of an untranslated regulatory sequence in the egfr gene contributes to early steps in breast cancer development.Semantic proximity Read ↗

Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations--a link between genetics and epigenetics.Semantic proximity Read ↗

Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence--first results of an inter-ethnic breast cancer study.Semantic proximity Read ↗

An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.Semantic proximity Read ↗

EGFR Intron 1 polymorphism in Asian Populations and its correlation with EGFR gene expression and amplification in breast tumor tissues.Semantic proximity Read ↗

Mechanisms of<i>egfr</i>Gene Transcription Modulation: Relationship to Cancer Risk and Therapy ResponseSemantic proximity Read ↗

Modification of Breast Cancer Risk in Young Women by a Polymorphic Sequence in the egfr GeneSemantic proximity Read ↗

Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression.Semantic proximity Read ↗

Association between the length of a CA dinucleotide repeat in the EGFR and risk of breast cancer.Semantic proximity Read ↗

Chromatin structure of the EGFR gene suggests a role for intron 1 sequences in its regulation in breast cancer cellsSemantic proximity Read ↗

A dinucleotide repeat in the mouse biglycan gene (EST) on the X chromosome.Semantic proximity Read ↗

Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.