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Article

Cloning of the gene and cDNA for human heart chymase.

1 Sept 1991

Abstract excerpt

We have recently identified and characterized a chymotrypsin-like serine proteinase in human heart (human heart chymase) that is the most catalytically efficient enzyme described, thus far, for the cleavage of angiotensin I to yield angiotensin II and the dipeptide His-Leu. Compared to other chymases, this enzyme also has an unusually high degree of specificity for the substrate angiotensin I. We report here the...

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PMID: 1894611
DOI: 10.1016/s0021-9258(19)47355-9

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