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Article

Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases.

The Journal of biological chemistry - 16 May 2008

Caughey George H, Beauchamp Jeremy, Schlatter Daniel, Raymond Wilfred W, Trivedi Neil N, Banner David, Mauser Harald, Fingerle Jürgen

Abstract excerpt

To explore guinea pigs as models of chymase biology, we cloned and expressed the guinea pig ortholog of human chymase. In contrast to rats and mice, guinea pigs appear to express just one chymase, which belongs to the alpha clade, like primate chymases and mouse mast cell protease-5. The guinea p...

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Share to Chymases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18353771
DOI: 10.1074/jbc.M710502200
PMCID: PMC2376239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18353771-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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