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Article

Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families

1 Aug 1993

Abstract excerpt

Prolylcarboxypeptidase, a lysosomal serine carboxypeptidase, cleaves COOH-terminal amino acids linked to proline, as in angiotensin II and III and [des-Arg9] bradykinin. About 25% of the enzyme protein was sequenced, and the complete sequence was deduced from its human kidney cDNA. The cDNA insert contained an open reading frame of 1488 base pairs coding for a protein of 496 residues. The authentic NH2-terminal...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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Identifiers

PMID: 8344943
DOI: 10.1016/s0021-9258(19)85465-0

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Source receipt: pubmed, retrieved 7 Sept 2026.

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