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Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.

1 May 1990

Abstract excerpt

Three different cDNAs and a gene encoding human skin mast cell tryptase have been cloned and sequenced in their entirety. The deduced amino acid sequences reveal a 30-amino acid prepropeptide followed by a 245-amino acid catalytic domain. The C-terminal undecapeptide of the human preprosequence is identical in dog tryptase and appears to be part of a prosequence unique among serine proteases. The differences...

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PMID: 2187193
DOI: 10.1073/pnas.87.10.3811

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