Article

Structural connectome architecture and biological vulnerability shape cortical atrophy in cocaine use disorder

2025-10-22

Abstract excerpt

<title>Abstract</title> <p>Background Cocaine use disorder (CUD) is highly prevalent and characterized by widespread gray matter atrophy across the cerebral cortex. Yet, it remains unclear whether and how connectome-based circuits and biological features shape these structural abnormalities. Methods We mapped cortical atrophy patterns in CUD (discovery cohort: N = 53; replication cohort: N = 74; controls: N = 364...

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Literature Corpus work: 529a8a17-cd0a-5e22-a128-e6698b4dd3ea
DOI: 10.21203/rs.3.rs-7656463/v1

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