Article

Structural connectome architecture and biological vulnerability shape cortical atrophy in cocaine use disorder

2025-08-15

Abstract excerpt

Cocaine use disorder (CUD) is prevalent and characterized by widespread gray matter atrophy across the cerebral cortex. However, it remains unclear whether and how connectome-based circuits and biological features shape these structural abnormalities. Here, we show that CUD-associated regional atrophy is constrained by the white matter (WM) structural connectome. Along these WM pathways, regions that share similar...

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Literature Corpus work: 3214cc0d-08f0-5869-8dc9-04442d6bc150
DOI: 10.1101/2025.08.11.669789

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