Article
Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy.
Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2009
Lei Cong, Niu Xiaolin, Wei Jin, Zhu Jianhong, Zhu Yi
Abstract excerpt
BACKGROUND: Keshan disease (KD) is a fatal dilated cardiomyopathy with unknown etiology. We studied the gene-environment interaction in the pathogenesis of KD by assessing the association of low blood selenium and polymorphisms in glutathione peroxidase-1 (GPx-1) gene. METHODS: The concentration of blood selenium and the activity and polymorphisms of GPx-1 in 71KD patients and 290 controls were measured. The...
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