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Article

Association of GSTT1/GSTM1 and ApoE variants with left ventricular diastolic dysfunction in thalassaemia major patients.

Hematology (Amsterdam, Netherlands) - 1 Dec 2019

Singh Mable Misha, Kumar Ravindra, Tewari Satyendra, Agarwal Sarita

Abstract excerpt

BACKGROUND: Cardiomyocytes are particularly susceptible to complications from iron loading. The blood transfusions in thalassaemia major create loading of iron that cannot be naturally excreted. Apolipoprotein E and Glutathione S-transferase act as the scavenger of free radicals, which are generated due to excess iron. The variants of Apolipoprotein E (ApoE) and Glutathione S-transferase (GST) may play a role in...

Topics

Adolescent
Adult
Apolipoproteins E
Child
Female
Genetic Predisposition to Disease
Glutathione Transferase
Humans
Male
Oxidative Stress
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ventricular Dysfunction, Left

beta-Thalassemia

Source

Identifiers

PMID: 30095041
DOI: 10.1080/10245332.2018.1502397

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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