Article
Canine fibroblast growth factor receptor 3 sequence is conserved across dogs of divergent skeletal size.
BMC genetics - 21 Oct 2008
Smith Logan B, Bannasch Danika L, Young Amy E, Grossman Deborah I, Belanger Janelle M, Oberbauer Anita M
Abstract excerpt
BACKGROUND: Fibroblast growth factor receptor 3 (FGFR3) is expressed in the growth plate of endochondral bones and serves as a negative regulator of linear bone elongation. Activating mutations severely limit bone growth, resulting in dwarfism, while inactivating mutations significantly enhance bone elongation and overall skeletal size. Domesticated dogs exhibit the greatest skeletal size diversity of any species...
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