Article
Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs.
Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2020
Abrams Sydney R, Hawks Alexandra L, Evans Jacquelyn M, Famula Thomas R, Mahaffey Mary, Johnson Gary S, Mason Jennifer M, Clark Leigh Anne
Abstract excerpt
Domesticated dogs show unparalleled diversity in body size across breeds, but within breeds variation is limited by selective breeding. Many heritable diseases of dogs are found among breeds of similar sizes, suggesting that as in humans, alleles governing growth have pleiotropic effects. Here, we conducted independent genome-wide association studies in the small Shetland Sheepdog breed and discovered a locus on...
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