Article
An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs.
Science (New York, N.Y.) - 21 Aug 2009
Parker Heidi G, VonHoldt Bridgett M, Quignon Pascale, Margulies Elliott H, Shao Stephanie, Mosher Dana S, Spady Tyrone C, Elkahloun Abdel, Cargill Michele, Jones Paul G, Maslen Cheryl L, Acland Gregory M, Sutter Nathan B, Kuroki Keiichi, Bustamante Carlos D, Wayne Robert K, Ostrander Elaine A
Abstract excerpt
Retrotransposition of processed mRNAs is a common source of novel sequence acquired during the evolution of genomes. Although the vast majority of retroposed gene copies, or retrogenes, rapidly accumulate debilitating mutations that disrupt the reading frame, a small percentage become new genes that encode functional proteins. By using a multibreed association analysis in the domestic dog, we demonstrate that...
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