Article
The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2012
Hoopes Barbara C, Rimbault Maud, Liebers David, Ostrander Elaine A, Sutter Nathan B
Abstract excerpt
Domestic dog breeds have undergone intense selection for a variety of morphologic features, including size. Among small-dog breeds, defined as those averaging less than ~15 in. at the withers, there remains still considerable variation in body size. Yet essentially all such dogs are fixed for the same allele at the insulin-like growth factor 1 gene, which we and others previously found to be a size locus of large...
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