Article
FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2017
Brown Emily A, Dickinson Peter J, Mansour Tamer, Sturges Beverly K, Aguilar Miriam, Young Amy E, Korff Courtney, Lind Jenna, Ettinger Cassandra L, Varon Samuel, Pollard Rachel, Brown C Titus, Raudsepp Terje, Bannasch Danika L
Abstract excerpt
Chondrodystrophy in dogs is defined by dysplastic, shortened long bones and premature degeneration and calcification of intervertebral discs. Independent genome-wide association analyses for skeletal dysplasia (short limbs) within a single breed (PBonferroni = 0.01) and intervertebral disc disease (IVDD) across breeds (PBonferroni = 4.0 × 10-10) both identified a significant association to the same region on...
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