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Article

Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2009

Graham J Dinny, Hanson Adrienne R, Croft Amanda J, Fox Archa H, Clarke Christine L

Abstract excerpt

The ovarian hormone progesterone is essential for normal breast development, and progesterone analogues are implicated in increasing breast cancer risk. The progesterone receptor (PR) is a transcription factor that, when ligand activated, moves rapidly into nuclear foci associated with transcriptional activity. However, the role of intranuclear trafficking signals in the focal location of PR is unknown. We have...

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PMID: 18931262
DOI: 10.1096/fj.08-113639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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