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Article

A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor.

British journal of pharmacology - 1 Sept 2003

Thompson Andrew J, Lummis Sarah C R

Abstract excerpt

1. To determine the mechanisms by which cation- or anion-specific channels select between these ions, we have examined the role of electrostatic factors in a typical ligand-gated ion channel, the 5-hydroxytryptamine3 (5-HT3) receptor, by removal and/or insertion of rings of conserved charged residues at either end of the pore. 2. Neutralization of the negatively charged ring at the intracellular end of the...

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Identifiers

PMID: 12970096
DOI: 10.1038/sj.bjp.0705424
PMCID: PMC1574024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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