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Cullin Family Proteins and Tumorigenesis: Genetic Association and Molecular Mechanisms

1 Jan 2015

Abstract excerpt

Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle progression. Clinically, cullin-associated E3 ligases have been identified to involve numerous...

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PMID: 25663940
DOI: 10.7150/jca.11076

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