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Article

Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype.

Stem cells (Dayton, Ohio) - 1 Jan 2009

Shibata Fumi, Goto-Koshino Yuko, Morikawa Yoshihiro, Komori Tadasuke, Ito Miyuki, Fukuchi Yumi, Houchins Jeffrey P, Tsang Monica, Li Dean Y, Kitamura Toshio, Nakajima Hideaki

Abstract excerpt

Roundabout (Robo) family proteins are immunoglobulin-type cell surface receptors that are expressed predominantly in the nervous system. The fourth member of this family, Robo4, is distinct from the other family members in that it is expressed specifically in endothelial cells. In this study, we examined the expression of Robo4 in hematopoietic stem cells (HSCs) and its possible role in HSC regulation. Robo4 mRNA...

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Identifiers

PMID: 18927479
DOI: 10.1634/stemcells.2008-0292
PMCID: PMC2883560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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