Article
Clinical and prognostic implications of Roundabout 4 (robo4) in adult patients with acute myeloid leukemia.
PloS one - 1 Jan 2015
Chen Yin-Kai, Hou Hsin-An, Tang Jih-Luh, Jhuang Jie-Yang, Lai Yan-Jun, Lee Ming-Cheng, Kuo Yuan-Yeh, Chou Wen-Chien, Liu Chieh-Yu, Lin Chung-Wu, Chuang Shih-Sung, Chen Chien-Yuan, Tseng Mei-Hsuan, Huang Chi-Fei, Chiang Ying-Chieh, Lee Fen-Yu, Liu Ming-Chih, Liu Chia-Wen, Yao Ming, Huang Shang-Yi, Ko Bor-Sheng, Hsu Szu-Chun, Wu Shang-Ju, Tsay Woei, Chen Yao-Chang, Tien Hwei-Fang
Abstract excerpt
BACKGROUND: Robo4 is involved in hematopoietic stem/progenitor cell homeostasis and essential for tumor angiogenesis. Expression of Robo4 was recently found in solid tumors and leukemia stem cells. However, the clinical implications of Robo4 expression in patients with acute myeloid leukemia (AML) remain unclear. METHODS: We investigated the clinical and prognostic relevance of mRNA expression of Robo4 in bone...
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