Article
Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells.
Trends in immunology - 1 Jul 2011
Nagasawa Takashi, Omatsu Yoshiki, Sugiyama Tatsuki
Abstract excerpt
In the bone marrow, hematopoietic stem cells (HSCs) are maintained by special microenvironments, termed niches. The nature and function of these niches, however, remains unclear. HSCs are thought be in contact with bone-lining osteoblasts, but recent studies have suggested that only a small subpopulation of HSCs reside in this endosteal niche. By contrast, many HSCs are associated with the sinusoidal endothelium,...
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