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Article

A stochastic single-molecule event triggers phenotype switching of a bacterial cell.

Science (New York, N.Y.) - 17 Oct 2008

Choi Paul J, Cai Long, Frieda Kirsten, Xie X Sunney

Abstract excerpt

By monitoring fluorescently labeled lactose permease with single-molecule sensitivity, we investigated the molecular mechanism of how an Escherichia coli cell with the lac operon switches from one phenotype to another. At intermediate inducer concentrations, a population of genetically identical cells exhibits two phenotypes: induced cells with highly fluorescent membranes and uninduced cells with a small number...

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Identifiers

PMID: 18927393
DOI: 10.1126/science.1161427
PMCID: PMC2819113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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