Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bacterial persistence as a phenotypic switch.

Science (New York, N.Y.) - 10 Sept 2004

Balaban Nathalie Q, Merrin Jack, Chait Remy, Kowalik Lukasz, Leibler Stanislas

Abstract excerpt

A fraction of a genetically homogeneous microbial population may survive exposure to stress such as antibiotic treatment. Unlike resistant mutants, cells regrown from such persistent bacteria remain sensitive to the antibiotic. We investigated the persistence of single cells of Escherichia coli with the use of microfluidic devices. Persistence was linked to preexisting heterogeneity in bacterial populations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microscopy
Share to Escherichia coli Proteins
Share to Mathematics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microfluidics

Share to Adaptation, Physiological

Share to Ampicillin

Share to Drug Resistance, Bacterial

Share to Drug Tolerance

Source

Identifiers

PMID: 15308767
DOI: 10.1126/science.1099390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bacterial persistence as a phenotypic switch.PMID 15308767Read ↗

The importance of being persistent: heterogeneity of bacterial populations under antibiotic stress.Semantic proximity Read ↗

New-found fundamentals of bacterial persistence.Semantic proximity Read ↗

A problem of persistence: still more questions than answers?Semantic proximity Read ↗

Microbial phenotypic heterogeneity and antibiotic tolerance.Semantic proximity Read ↗

Memory and fitness optimization of bacteria under fluctuating environments.Semantic proximity Read ↗

Antibiotic Tolerance Indicative of Persistence Is Pervasive among Clinical Streptococcus pneumoniae Isolates and Shows Strong Condition Dependence.Semantic proximity Read ↗

Bacterial persistence: a model of survival in changing environments.Semantic proximity Read ↗

Antibiotic-tolerant persisters are pervasive among clinical <i>Streptococcus pneumoniae</i> isolates and show strong condition-dependenceSemantic proximity Read ↗

Phenotypic heterogeneity in bacteria: the rise of antibiotic persistence, clinical implications, and therapeutic opportunities.Semantic proximity Read ↗

Ecology and evolution of antibiotic persistence.Semantic proximity Read ↗

Bacterial Persistence Modulates the Speed, Magnitude, and Onset of Antibiotic Resistance Evolution.Semantic proximity Read ↗

Phenotypic and genetic heterogeneity within biofilms with particular emphasis on persistence and antimicrobial tolerance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.