Article
Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping.
Diabetologia - 1 Jul 1990
Jenkins D, Mijovic C, Fletcher J, Jacobs K H, Bradwell A R, Barnett A H
Abstract excerpt
A major component of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus has been mapped to the major histocompatibility complex. Certain gene alleles in this region determine susceptibility and resistance to the disease. Mapping of susceptibility is hindered by the limitations of conventional tissue typing techniques, and by strong linkage disequilibrium within this part of the genome....
Topics
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Humans
- Major Histocompatibility Complex
- Polymorphism, Restriction Fragment Length
- Racial Groups