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Article

Focal adhesion kinase controls aggressive phenotype of androgen-independent prostate cancer.

Molecular cancer research : MCR - 1 Oct 2008

Johnson Thomas R, Khandrika Lakshmipathi, Kumar Binod, Venezia Sarah, Koul Sweaty, Chandhoke Ryan, Maroni Paul, Donohue Robert, Meacham Randall B, Koul Hari K

Abstract excerpt

Overexpression of focal adhesion kinase (FAK) has been well correlated with tumor development and/or the maintenance of tumor phenotype. In addition, inappropriate activation of the extracellular regulated kinase (ERK) signaling pathway is common to many human cancers. In the present study, we investigated the interplay between FAK and ERK in androgen-independent prostate cancer cells (PC3 and DU145 cells). We...

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PMID: 18922979
DOI: 10.1158/1541-7786.MCR-08-0052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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